An Experimental Study on Radioprotective Effect of DDC, MEA, and WR-2721

DDC, MEA, WR-2721의 방사선(放射線) 방호효과(防護效果)에 관(關)한 연구(硏究)

  • Chung, In-Young (Lab. of Radiation Hazard. Korea Cancer Center Hospital) ;
  • Koh, Joo-Hwan (Lab. of Radiation Hazard. Korea Cancer Center Hospital) ;
  • Chung, Hyun-Woo (Lab. of Radiation Hazard. Korea Cancer Center Hospital) ;
  • Chil, Soo-Yil (Lab. of Radiation Hazard. Korea Cancer Center Hospital) ;
  • Yoo, Seong-Yul (Dept. of Therapeutic Radiology Korea Cancer Center Hospital) ;
  • Koh, Kyoung-Hwan (Dept. of Therapeutic Radiology Korea Cancer Center Hospital)
  • 정인용 (원자력병원 방사선인체장해연구실) ;
  • 고주환 (원자력병원 방사선인체장해연구실) ;
  • 정현우 (원자력병원 방사선인체장해연구실) ;
  • 진수일 (원자력병원 방사선인체장해연구실) ;
  • 유성열 (원자력병원 치료방사선과) ;
  • 고경환 (원자력병원 치료방사선과)
  • Published : 1986.12.15

Abstract

At present, the treatments of the radiation-induced diseases are only performing by the palliative treatment technique. Moreover, radiation protective agents are a little toxic for human being and this seriously limits their applicability with various complications in clinical uses. Accordingly, as a part of the aim of gain of the basic data for protective roles of some radioprotectors, the present investigation was carried out to evaluate the comparative radioprotective effects by the administration of DDC, MEA, WR-2721. Results are shown for statistically significant analysis and correlation with each group as follows; 1. The proper doses of the radioprotectors were DDC; 1,550 mg/kg, MEA; 450 mg/kg, WR-2721; 780 mg/kg of the mouse body weight. 2. DMF(Dose modification factor) of LD 50/10 and LD 50/30 for whole body irradiation was DDC; 1.2, MEA; 1.4, WR-2721; 1.9 and DDC; 1.7, MEA; 1.8, WR-2721; 2.5 respectively. 3. DMF for radiation reaction of jejunal crypt was DDC: 1.07, MEA: 1.21 and WR-2721: 1.76 and that of jejunal crypt cell was DDC: 1.04, MEA: 1.08 and WR-2721: 1.38 respectively. 4. Conclusively, WR-2721 was the most effective drung among the three radioprotectors and this result must be a supportive data for further study for clinical application.

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