A Possible Enzymatic Catabolism of L-Ascorbic Acid via $\alpha$-Ketoaldehydes

L-Ascorbic Acid의 생체분해

  • 강사욱 (서울대학교 자연과학대학교 미생물학과)
  • Published : 1985.12.01


It is shown by means of nuclear magnetic resonance spectroscopy that 3,4,5-trihydroxy-2-keto-L-valeraldehyde (L-xylosone), an ${\alpha}$-ketoaldehyde, is formed during the oxidative catabolism of L-ascorbic acid. It is proposed that this substance serves as a substrate for the glyoxalase system by which it is transformed to L-xylonic acid. As L-xylonic acid is further oxidized to L-erythroascorbic acid, a biochemical pathway is proposed for the action of vitamin C which consists of two further ${\gamma}$-lactones and three different substrates of the glyoxalase system.