Effects of Excess Vitamin E and Cholesterol Supplements on Levels of Vitamin E and Cholesterol in Rat Serum and Liver

과량의 비타민 E 및 Cholesterol 첨가식이가 흰쥐의 혈청과 간의 비타민 E 및 Cholesterol 농도에 미치는 영향

  • Hwang, K.D. (Dept. of Food & Nutrition, College of Home Economics Yonsei University) ;
  • Kim, H.M. (Dept. of Food & Nutrition, College of Home Economics Yonsei University) ;
  • Kim, J.M. (Dept. of Food & Nutrition, College of Home Economics Yonsei University) ;
  • Lee, Y.C. (Dept. of Food & Nutrition, College of Home Economics Yonsei University)
  • 황금단 (연세대학교 가정대학 식생활학과) ;
  • 김형미 (연세대학교 가정대학 식생활학과) ;
  • 김정미 (연세대학교 가정대학 식생활학과) ;
  • 이양자 (연세대학교 가정대학 식생활학과)
  • Published : 1985.06.30

Abstract

The present study was undertaken to investigate the effects of excess vitamin E supple-mentation (0.5%) and cholesterol (0.5%) on levels of serum and liver vitamin E and cholesterol in two categories of rats, group A and group B. Rats in group A(45-65g) were fed experimental diets for 3 weeks ( I-C, II-E, III-Ch, IV-ECh). On the other hand rats in group B(45g-65g) were first fed control diet for 3 weeks and then fed experimental diets when they were 100-l20g for the subsequent 3 weeks ( I'-C, II'-E, III'-Ch, & IV'-ECh). The levels of serum vitamin E were higher in vitamin supplemented groups as expected. Dietary cholesterol showed a tendency to lower serum vitamin E levels of vitamin E supplemented groups. Serum cholesterol levels tended to stay in a narrow range showing resistancy to dietary cholesterol and were not affected by vitamin E status. Whereas vitamin E supplementation seemed to lower the levels of hepatic cholesterol in both groups A & B( I-C, I'-C vs II-E, II'-E ), simultaneous supplementation of vitamin E with 0.5% cholesterol appeared to increase further the hepatic cholesterol levels which were already increased by cholesterol feeding ( IV-ECh, IV'-ECh, vs III- Ch, III'-Ch). Hepatic vitamin A levels decreased as rats grew older during the experimental period. Even though vitamin A levels did not differ from each other significantly, excess amount of vitamin E supplementation in group B seemed to show a tendency to decrease the vitamin A storage in liver.

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