Drug Toxicities of S-2-(W-aminoalkylamino) ethyl and S-2, W-diaminoalkyl Isothiuronium Bromides and their Potent Radioprotective Effects

S-2, - (W-aminoalkylamino) ethyl 및 S-2, W-diaminoalkyl Isothiuronium Bromide 의 약독성(藥毒性)과 방사선장해방호(放射線障害防護) 효과

  • Kim, You-Sun (Reactor Chemistry Laboratory, Korea Advanced Energy Research Institute) ;
  • Kim, Suc-Won (Reactor Chemistry Laboratory, Korea Advanced Energy Research Institute)
  • 김유선 (한국에너지연구소, 원자제화학연구실) ;
  • 김석원 (한국에너지연구소, 원자제화학연구실)
  • Published : 1985.12.20

Abstract

S-2, W-diaminopentyl isothiuronium bromide and relevant thiophosphate derivative were prepared starting from both phthalimide and l-ornithinic acid. Drug toxicities of the prepared isothiuronium bromide and S-2-(W-aminoalkylamino) ethyl isothiuronium bromides were tested through ICR male mice, 4 and 8 weeks old and weighing $25{\sim}35g$. The former compound was found to be less toxic than those of latter compounds. This difference of drug toxicities seemed to be originated from their chemical structures, which were examined through IR Spectrometry Radioprotective effects of these compounds were discussed through relevant research data and diaminopentyl derivatives are considered to be a potent radioprotectant with low drug toxicity.

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