Radioprotective Effects of Cysteamine, Isothiouronium Derivatives and Their Combinations with a Phosphorothioate

Cysteamire, Isothiouronium 유도체(誘導體) 및 이들과 Phosphorothioate와의 혼합물(混合物)들의 방사선(放射線) 방호효과(防護效果)

  • Kim, You-Sun (Reactorchemistry Lab., Korea Advanced Energy Research Institute) ;
  • Kim, Ok-Hee (Reactorchemistry Lab., Korea Advanced Energy Research Institute)
  • 김유선 (한국에너지연구소.원자로화학연구소) ;
  • 김옥희 (한국에너지연구소.원자로화학연구소)
  • Published : 1982.08.31

Abstract

Cysteamine(Mercaptoethyiamine, MEA), S,2-Aminoethylisothiouronium Bromide. HBr (AET), and S-(2-Aminoethyl) Dihydrogen Phosphorothioate (WR-638) were prepared and radioprotective effects of these chemicals and their combinations against $^{60}Co$ ${\gamma}-ray$ radiation were studied ,in irradiated ICR mice. Intraperitonially administered chemicals or their combinations resulted drug deaths in cases of MEA, AET, and their combinations, whereas there were a slight or no drug death in cases of WR-638 and the combination of AET with WR-638. All tested chemicals and their combinations yielded radioprotective effects against $^{60}Co$ $\gamma-ray$ radiation. An additive radioprotection effect was observed in case of the combination of AET with WR-638.

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