- Volume 5 Issue 1
Chemical modifying agents of radiation effect
방사선조사(放射線照射)의 생물학적효과(生物學的效果)에 영향을 미치는 약제(藥劑)
- Han, Man-Chung (Department of Radiology, College of Medicine, Seoul National University) ;
- Chang, Kee-Hyun (Department of Radiology, College of Medicine, Seoul National University)
- Published : 1980.12.30
A number of chemical compounds that modify radiation effects are reviewed, with brief report of our own experiments on radioprotective effect of some vasoconstrictive agents and 5-Thio-D-Glucose. Sulfhydryl compounds(-SH group) and some pharmacologic compounds such as CNS depresants, vasoconstrictive agents and autonomic drugs are known to have radioprotective effect in experimental research and in limitted clinical study, whereas oxygen, hallogenated pyrimidines and metronidazole, etc. have radiosensitizing effect. Author experimentally observed some radioprotective effects of angiotensin II, a strong vasoconstrictor, and 5-Thio-D-glucose in mice.