Studies on the Production of Chlortetracycline (Part 1) The Effect of Carbon Source and Mineral Ions

Chlortetracycline 발효에 관한 연구 (제1보) 탄소원과 2 가금속이온의 영향

  • Kim, Seong-Ung (Dong A Pharm. Co., Ltd) ;
  • Dewey D.Y. Ryu (Korea .Advanced Institute of Science Department of Biological Science and Engineering)
  • Published : 1978.09.01


Improvement of fermentation medium for chlortetracycline production was attempted. Starch was a good carbon source for chiortetracycline production as compared with sucrose or glucose, although the cell yield from the starch medium was somewhat lower, and complexed natural medium was more suitable than artificial and simple one for this purpose. The concentrations of divalent ions, such as $Mg^{2+}$, M $n^{2+}$, Z $n^{2+}$, and F $e^{2+}$, affected the productivity of chlortetracycline. These mineral ions in excess of which was contained in natural medium such as corn flour and corn steep liquor, caused significant decrease in the productivity of chlortetracycline.cline.