Photochemical Synthesis of Aspartylphenylalanyl Methyl Ester

광 알킬화 반응에 의한 Aspartylphenylalanyl Methyl Ester의 합성

  • Sang Chul Shim (Department of Chemical Science, Korea Advanced Institute of Science) ;
  • Kyu Ho Chae (Department of Chemical Science, Korea Advanced Institute of Science)
  • 심상철 (한국과학기술원 화학 및 화학공학과) ;
  • 채규호 (한국과학기술원 화학 및 화학공학과)
  • Published : 1975.10.30

Abstract

Glycine residue in N-X-glycylphenylalanine methyl ester(X = trifluoroacetyl or acetyl) was converted into aspartic acid derivative by a photoalkylation reaction. The reaction was induced with 350 nm lamp using a combination of diacetyl/di-t-butyl peroxide (DBP) as the photoinitiator, and acetic anhydride as the alkylating agent. In the thermal reaction with DBP and acetic anhydride, the same alkylation reaction of the dipeptide was observed. From this thermal alkylation reaction the photoalkylation reaction is also thought to undergo via free radical mechanism.

Keywords

References

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