A Biopharmaceutical Study on the Absorption of Some Compounding Drugs

배합약물(配合藥物)의 흡수(吸收)에 관(關)한 생물약제학적(生物藥劑學的) 연구(硏究) 1. Salicylamide에 항(抗) Histamine제(劑)를 배합(配合)하였을 때의 흡수효과에 관(關)하여

  • Kim, Jae-Wan (Faculty of Pharmacy, Duk Sung Women's College)
  • Published : 1971.11.20

Abstract

The comparative studies were made on Salicylamide, used individually and compounded with antihistaminics as regards. (1) the absorption rate through isolated rat small intestine (in vitro) (2) the absorption rate through rat small intestine (in vivo), and the following effects were found. 1. The Absorption velosity of 2 m Mole gm. of salicylamide in the small intestine were decreased, when the agents compounded with tripelennamine indicating the greatest absorption inhibition in the case of m Mole gm. of tripelennamine. 2. The Absorption velosity of 2m Mole gm. of salicylamide in the small intestine were decreased, when the agents compounded with diphenhydramine indicating the greatest absorption inhibition in the case of 2m Mole gm. of diphenhydramine. 3. The Absorption velosity of 2m Mole gm. of salicylamide in the small intestine were increased, when the agents compounded with chlorpheniramine indicating the greatest absorption augmentation in the case of 0.2m Mole gm. of chlorpheniramine.

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