# X-선조사(線照射)를 입은 Ehrlich 복수담암(腹水擔癌)마우스의 간(肝) 및 신조직(腎組織)의 산소소비량(酸素消費量) 및 단백량(蛋白量)에 대(對)하여

• Choi, Byung-Ok (Department of Physiology, Kyungpook National University School of Medicine) ;
• Choo, Young-Eun (Department of Physiology, Kyungpook National University School of Medicine)
• 최병옥 (경북대학교 의과대학 생리학교실) ;
• 주영은 (경북대학교 의과대학 생리학교실)
• Published : 1969.06.01

#### Abstract

Oxygen consumption rate $(QO_2)$ and protein content of liver and kidney of the Ehrlich ascites tumor-bearing mouse were measured from 6th till 14th day after the inoculation of $4{\times}10^6$ Ehrlich ascites tumor cells. The results thus obtained were compared with those of the groups in which; 1) Whole body x-irradiation with 400 r was done to mouse prior to the inoculation of $4{\times}10^6$ Ehrlich ascites tumor cells, 2) Same number of the irradiated tumor cells were inoculated after subjecting the tumor cells to x-irradiation with 400 r or 900 r in vitro, and 3) the normal, and the following results were obtained; 1. $QO_2$ of the liver and kidney of the tumor-bearing mouse were all lower than the normal and a gradual decrease of $QO_2$ in both liver and kidney was noted as the ascites tumor was progressively developing. 2. In the groups where whole body x-irradiation with 400 r was done, or x-irradiation of ascites tumor cells in vitro with either 400 r or 900 r, $QO_2$ of the liver and kidney were lower than the normal, and the pattern of the decrease was similar in the case of the tumor-bearing mouse. 3. Protein contents in all the groups showed lower values than the normal, and the decrease was gradual as the ascites tumor was developing. 4. $QO_2$ and protein levels in the liver were generally lower than those in the kidney. 5. A certain cancerous metabolism was, therefore, noted in the remote organs of Ehrlich ascites tumor-bearing animal.