Three-Dimensional Self-Assembly of Gold Nanoparticles Using a Virus Scaffold

  • Kang, Aeyeon (Department of Chemistry, Sungkyunkwan University (SKKU)) ;
  • Lee, Young-Mi (Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biothechnology (KRIBB)) ;
  • Kang, Hyo Jin (Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biothechnology (KRIBB)) ;
  • Chung, Sang Jeon (Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biothechnology (KRIBB)) ;
  • Yun, Wan Soo (Department of Chemistry, Sungkyunkwan University (SKKU))
  • Published : 2013.02.18

Abstract

Templated strategy is a very powerful tool for creating multi-dimensional self assembly of nanomaterials. Since viral protein cages have a uniform size with a well-defined structure, they can serve as an excellent template for the formation of a three-dimensional self-assembly of synthetic nanoparticles. In this study, we have examined the feasibility of the 3D self-assembly of gold nanoparticles of various sizes using a brome mosaic virus (BMV) capsid with cysteine groups expressed on its surface as a scaffold for the assembly. It was found that the three-dimensional clusters of gold nanoparticles with a designed structure were attainable by this approach, which was verified by transmission electron microscope (TEM) and dynamic light scattering (DLS) analysis.