Unprecedented Molecular Architectures by the Controlled Self-Assembly of ${\beta}$-Peptide Foldamer

  • Kwon, Sun-Bum (Molecular-Level Interface Research Center, Department of Chemistry, KAIST) ;
  • Lee, Hee-Seung (Molecular-Level Interface Research Center, Department of Chemistry, KAIST)
  • Published : 2011.08.17

Abstract

During past decades, several types of peptide-based scaffolds, ranging from simple aromatic dipeptide to small protein fragments, have been studied to understand the underlying mechanism and mimic to create artificial nano/microstructures. However, a limited number of design principles have still been reported in peptidic scaffolds allowing well-defined self-assembled structure formation, presumably due to the intrinsic large conformational flexibility of natural peptides. In this presentation, we report the first example of highly homogeneous, well-defined and finite architectures by the ${\beta}$-peptide self-assembly.