Anticancer Loaded Multi-wall Carbon Nanotube for Targeting Tumors

  • Wang, Wenping (School of Materials Science and Engineering and PRC for NBECS, Gyeongsang National University) ;
  • Choi, Jung-Il (Department of Anatomy, Institute of Health Science and School of Medicine, Gyeongsang National University) ;
  • Kang, Sang-Soo (Department of Anatomy, Institute of Health Science and School of Medicine, Gyeongsang National University) ;
  • Nam, Tae-Hyun (School of Materials Science and Engineering and PRC for NBECS, Gyeongsang National University) ;
  • Khang, Dong-Woo (School of Materials Science and Engineering and PRC for NBECS, Gyeongsang National University)
  • Published : 2011.05.27

Abstract

Flat form technology for constructing anticancer loaded multi-walled carbon nanotubes (mwCNTs) was introduced in this study. Conventional anticancer drugs, such as MTX (Methotrexate), cisplatin, DOX (Doxorubicin hydrochloride), DAU (Daunorubicin) and EPI (epirubicin) were bio-conjugated with folic acid (FA) for selective targeting tumor cells. Loading efficiencies of the used anticancer drugs on mwCNTs have shown different order of bindings depending on the molecular bind affinity of NH (amine) formation on mwCNTs. MTT assays have shown increased selective target efficiency of FA conjugated mwCNTs on breast cancer cell growth inhibition. All results collectively indicated promising application of mwCNTs as a smart inorganic nanomaterial for selective targeting drug delivery vehicle at tumor tissues.