# Determination of Letrozole in formulation by a Validated RP-HPLC method

• Published : 2010.05.28

#### Abstract

A simple, rapid and validated reverse d phase liquid chromatographic method has been developed for the determination of Letrozole (LZ) in pharmaceutical dosage. LZ was separated on ODS analytical column with a mixture of acetonitrile, water in the ratio 50:50 (v/v) as mobile phase at a flow rate of 1.0 mL /min. The effluent was monitored by UV detection at 265nm. Calibration plot was linear in the range of 160 to $240{\mu}g$/mL with the linear regression (r) = 0.999. The method was validated for recovery, precision, specificity.