Recently, many researchers have studied on RFID with the rapid development of RFID technologies. RFID adapts to many applications. A lot of readers may be deployed in some applications. The incorrect deployment of RFID readers occurs reader-to-reader interferences in many applications using RFID technologies. It causes the significant degradation of the RFID recognition rate. Therefore, it is very important to appropriately deploy the RFID readers in terms of costs and system performance. In this paper, we propose a novel RFID sensor network design system with the minimal RFID readers to cover whole regions when an arbitrary blueprint is given.