C/EBP$\beta$ and Nrf2-Mediated GSTA2 Induction by $\alpha$-Lipoic acid, an Insulin-Sensitizing Agent that has Antioxidant and Prooxidant Activities

  • Ki, Sung-Hwan (National Research Laboratory, College of Pharmacy) ;
  • Cho, Il-Je (Research Institute of Pharmaceutical Sciences, Seoul National Universit) ;
  • Kim, Sang-Geon (Research Institute of Pharmaceutical Sciences, Seoul National University)
  • Published : 2003.10.01


The protective adaptive response to electrophiles and reactive oxygen species is mediated by enhanced expression of phase II detoxifying genes including glutathione S-transferases. ${\alpha}$-Lipoic acid, which exerts prooxidant or antioxidant activities, has been shown to activate the insulin signaling pathway and thus to induce insulin-like actions via PI3-kinase and Akt. Our previous studies have shown that PI3-kinase plays an essential role in Nrf2-or C/EBP${\beta}$-mediated glutathione S-transferase A2 (GSTA2) induction. (omitted)