Cytotoxic activity of 1-phenyl-2-substituted thiourea derivatives

  • Im, C.U. (College of Pharmacy. Chung-ang University) ;
  • Park, Sang-Min (College of Pharmacy. Chung-ang Universit) ;
  • Jun, S.C. (College of Pharmacy. Chung-ang Universit) ;
  • Yim, C.B. (College of Pharmacy. Chung-ang University)
  • Published : 2002.10.01


The 20 thiourea derivatives had been investigated for their cytotoxic activity using MTT assay. Cytotoxic activity was strongly influenced by the substituted alkyl chain length. but not by configuration of Cl and C2. The optimal alkyl chain length for cytotoxicity was C12. The 9 thiourea derivatives showed stronger activity than reference compound. B13. some of them gave 2-3 times stronger activity than B13. (omitted)