MICRONUCLEI INDUCTION BY REPEATED INHALATION EXPOSURE TO THE 1,1-DICHLORO-1-FLUOROETHANE BUT NOT BY THE SINGLE PERITONEAL INJECTION

  • Maeng, Seung-Hee (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agency) ;
  • Chung, Hai-Won (School of Public Health, Seoul National Universit) ;
  • Kim, Hyun-Young (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agenc) ;
  • Lim, Cheol-Hong (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agenc) ;
  • Lee, Jong-Yoon (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agenc) ;
  • Chung, Yong-Hyun (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agenc) ;
  • Lee, Yong-Mook (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agenc) ;
  • Chung, Ho-Keun (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agenc) ;
  • Yu, Il-Je (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety & Health Agency)
  • Published : 2001.10.01

Abstract

To investigate the genotoxic effect of 1, 1-dichloro-1-fluoroethane which was widely used as a cleaning solvent at the electronic part industry, the micronucleus frequencies were recorded by examining polychromatic erythrocytes in bone marrows of single i.p. injected mice at high doses and of the repeatedly inhaled rats for 13 weeks at relatively low concentrations.(omitted)

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