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Caloric restriction and its mimetics
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  • Journal title : BMB Reports
  • Volume 46, Issue 4,  2013, pp.181-187
  • Publisher : Korean Society for Biochemistry and Molecular Biology
  • DOI : 10.5483/BMBRep.2013.46.4.033
 Title & Authors
Caloric restriction and its mimetics
Lee, Shin-Hae; Min, Kyung-Jin;
  PDF(new window)
 Abstract
Caloric restriction is the most reliable intervention to prevent age-related disorders and extend lifespan. The reduction of calories by 10-30% compared to an ad libitum diet is known to extend the longevity of various species from yeast to rodents. The underlying mechanisms by which the benefits of caloric restriction occur have not yet been clearly defined. However, many studies are being conducted in an attempt to elucidate these mechanisms, and there are indications that the benefits of caloric restriction are related to alteration of the metabolic rate and the accumulation of reactive oxygen species. During molecular signaling, insulin/insulin-like growth factor signaling, target of rapamycin pathway, adenosine monophosphate activated protein kinase signaling, and Sirtuin are focused as underlying pathways that mediate the benefits of caloric restriction. Here, we will review the current status of caloric restriction.
 Keywords
Caloric restriction;CR mimetics;Lifespan extension;Longevity;
 Language
English
 Cited by
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